• HOME
  • Introduction
  • News&Announcements
news view
Subject Team Lead by Prof. Ki Hoon Ahn, In-Seok Song, Kwang-Sig Lee, Eun-Seon Kim Identified Significance of Emesis Gravidarum as a Determinant of Premature Birth Using AI Analysis
Selection News Date 2020-03-23 Read 97

Team Lead by Prof. Ki Hoon Ahn, In-Seok


Song, Kwang-Sig Lee, Eun-Seon Kim



Identified Significance of Emesis Gravidarum


as a Determinant of Premature Birth


Using AI Analysis





Gastroesophageal reflux disease manifested by morning


sickness and heartburn has 2.88 times variable importance for


premature birth than periodontitis



Periodontitis is reported to be associated with preterm birth. Recently,


however, a study showing that morning sickness is related to preterm


birth has been published and receiving attention from academia. 



A joint research team of Prof. Ki Hoon Ahn of Department of Obstetrics


and Gynecology of Korea University Anam Hospital, Prof. In-Seok


Song of Department of Dentistry, Prof. Kwang-Sig Lee of AI Center,


Prof. Eun-Seon Kim of Department of Gastroenterology analyzed the


link between gastroesophageal reflux disease (GERD), periodontitis, and


preterm birth with machine learning, and found that GERD has 2.88


times variable importance for preterm birth than periodontitis.



The research team analyzed 731 patients’ maternal data received from


Korea University Anam Hospital using a random forest ML algorithm.



Based on variable importance from the random forest, the major


determinant of preterm birth is body mass indexes (BMI) followed by


age, parity, systolic blood pressure, twin, and education. GERD ranked


13th and periodontitis ranked 22nd.



GERD is a common disease in Korea, where about 4.5 million people


are treated annually. GERD can present as morning sickness during


pregnancy, and morning sickness is a common symptom of pregnancy in


which 8 out of 10 women experience. Even the people without GERD


can end up with GERD with morning sickness due to frequent gastric


acid reflux and weakening of the lower esophageal sphincter, or GERD


can be exacerbated if one already has pre-pregnancy GERD and


experience morning sickness.



“Because it’s a common symptom, you can misunderstand that it’s not


dangerous. However, it’s a good idea to minimize the risk factors, if you


can, for a healthy delivery,” Prof Ahn said. “If you experience morning


sickness and do not think much about it because it’s so common, the


diagnosis of GERD may be delayed and the disease can be exacerbated,


leading to a risk factor for preterm birth, so it is advisable to proactively


seek consultation with specialty physicians.”



“Determinants of Spontaneous Preterm Labor and Birth Including


Gastroesophageal Reflux Disease and Periodontitis” was published in


the latest issue of Journal of Korean Medical Science (JKMS) garnering


academic attention from home and abroad. Prof. Ahn is conducting


numerous studies to prevent premature birth and deliver a healthy baby.


He identified the significance of obesity, blood pressure, blood glucose


level, cervical injury as a risk factor for preterm birth using artificial


neural network analysis last year, and is researching using AI the early


diagnosis and treatment of preterm birth.

Contents manager