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Subject Team Lead by Prof. Ki Hoon Ahn, In-Seok Song, Kwang-Sig Lee, Eun-Seon Kim Identified Significance of Emesis Gravidarum as a Determinant of Premature Birth Using AI Analysis
Selection News Date 2020-03-23 Read 97

Team Lead by Prof. Ki Hoon Ahn, In-Seok

 

Song, Kwang-Sig Lee, Eun-Seon Kim

 

 

Identified Significance of Emesis Gravidarum

 

as a Determinant of Premature Birth

 

Using AI Analysis

 

 

  

 

Gastroesophageal reflux disease manifested by morning

 

sickness and heartburn has 2.88 times variable importance for

 

premature birth than periodontitis

 

 

Periodontitis is reported to be associated with preterm birth. Recently,

 

however, a study showing that morning sickness is related to preterm

 

birth has been published and receiving attention from academia. 

 

 

A joint research team of Prof. Ki Hoon Ahn of Department of Obstetrics

 

and Gynecology of Korea University Anam Hospital, Prof. In-Seok

 

Song of Department of Dentistry, Prof. Kwang-Sig Lee of AI Center,

 

Prof. Eun-Seon Kim of Department of Gastroenterology analyzed the

 

link between gastroesophageal reflux disease (GERD), periodontitis, and

 

preterm birth with machine learning, and found that GERD has 2.88

 

times variable importance for preterm birth than periodontitis.

 

 

The research team analyzed 731 patients’ maternal data received from

 

Korea University Anam Hospital using a random forest ML algorithm.

 

 

Based on variable importance from the random forest, the major

 

determinant of preterm birth is body mass indexes (BMI) followed by

 

age, parity, systolic blood pressure, twin, and education. GERD ranked

 

13th and periodontitis ranked 22nd.

 

 

GERD is a common disease in Korea, where about 4.5 million people

 

are treated annually. GERD can present as morning sickness during

 

pregnancy, and morning sickness is a common symptom of pregnancy in

 

which 8 out of 10 women experience. Even the people without GERD

 

can end up with GERD with morning sickness due to frequent gastric

 

acid reflux and weakening of the lower esophageal sphincter, or GERD

 

can be exacerbated if one already has pre-pregnancy GERD and

 

experience morning sickness.

 

 

“Because it’s a common symptom, you can misunderstand that it’s not

 

dangerous. However, it’s a good idea to minimize the risk factors, if you

 

can, for a healthy delivery,” Prof Ahn said. “If you experience morning

 

sickness and do not think much about it because it’s so common, the

 

diagnosis of GERD may be delayed and the disease can be exacerbated,

 

leading to a risk factor for preterm birth, so it is advisable to proactively

 

seek consultation with specialty physicians.”

 

 

“Determinants of Spontaneous Preterm Labor and Birth Including

 

Gastroesophageal Reflux Disease and Periodontitis” was published in

 

the latest issue of Journal of Korean Medical Science (JKMS) garnering

 

academic attention from home and abroad. Prof. Ahn is conducting

 

numerous studies to prevent premature birth and deliver a healthy baby.

 

He identified the significance of obesity, blood pressure, blood glucose

 

level, cervical injury as a risk factor for preterm birth using artificial

 

neural network analysis last year, and is researching using AI the early

 

diagnosis and treatment of preterm birth.

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