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Subject A team led by Professor Kim Sung-eun of Department of Nuclear Medicine Proposed a New Prognosis Predictive Model for Breast Cancer
Selection News Date 2020-03-30 Read 106

A team led by Professor Kim Sung-eun of

 

Department of Nuclear Medicine Proposed

 

a New Prognosis Predictive Model

 

for Breast Cancer

 

 

  

 

 

Investigates Visceral Fat Metabolic Activity after Menopause

 

and the Correlation with Axillary Lymph Node Metastasis

 

 

Obesity is known to be associated with a poor prognosis of breast cancer

 

and obesity-driven dysfunctional metabolic activity in visceral adipose

 

tissue is considered as one of the principal underlying mechanisms. The

 

association with axillary lymph node metastasis, which is an important

 

prognostic factor for obesity and breast cancer in postmenopausal

 

women, has been investigated for the first time in the world receiving

 

attention from academia.

 

 

Accumulating evidence supported that obesity increases the mortality

 

and morbidity in postmenopausal breast cancer. However, little was

 

known about the relationship with the metabolic activity of

 

dysfunctional visceral adipose tissue, a principal underlying mechanism

 

of obesity. A research team led by Prof. Kim Sung-eun and Park Ki-soo

 

of the Department of Nuclear Medicine of Korea University Anam

 

Hospital investigated the association between visceral fat metabolic

 

activity and axillary lymph node metastasis in postmenopausal breast

 

cancer.

 

 

Research on 173 breast cancer surgery patients who underwent

 

preoperative PET/CT revealed that the higher visceral fat metabolic

 

activity is associated with the higher axillary lymph node metastasis

 

which is an important prognostic factor determining the method of

 

treatment and the survival rate of breast cancer.

 

 

“Visceral fat metabolism activity can be evaluated with positron-

 

emission tomography (PET) or computerized tomography (CT) which is

 

a well-known nuclear medicine imaging modality, and this study will

 

help us to better understand the association between obesity and breast

 

cancer which are rising rapidly in postmenopausal women,” Prof. Kim

 

Sung-eun stated. “It is expected to have a positive effect on predicting

 

the effectiveness of diagnosis and treatment in women with

 

postmenopausal breast cancer.”

 

 

“Visceral fat metabolic activity evaluated by preoperative 18F-FDG

 

PET/CT significantly affects axillary lymph node metastasis in

 

postmenopausal luminal breast cancer” was published in the latest

 

Scientific Reports, a sister journal of Nature, receiving international

 

attention from academia.

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