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Subject Research Team of KU Guro Hospital, Proposed New Technology to Predict Impairment in Patients During Acute Phase of Stroke
Selection News Date 2020-06-30 Read 56

Co-Research Team of the Cardiovascular

Center and Neurological Disorders Center

of Korea University Guro Hospital,

Proposed New Technology to Predict

Impairment in Patients During Acute

Phase of Stroke

  

 

 

Analysis of Sleep-Disordered Breathing with Holter Monitoring Can

 

Help Predict Functional Impairment

 

 

The Presence of Sleep-Disordered Breathing at the Early Stage of

 

Stroke Showed a 4-Fold Increased Risk of Severe Functional

 

Impairment

 

 

It is widely known that the presence of sleep-disordered breathing (SDB) at the

 

early stage of stroke is a risk factor of neurological impairment and delayed

 

recovery. However, assessing the presence of SDB with either conventional

 

polysomnography or respiratory recording devices during the acute phase of

 

stroke has limited effectiveness.

 

 

According to the co-research team of the Cardiovascular Center and

 

Neurological Disorders Center of Korea University Guro Hospital (from left to

 

right, Professor Jin Oh Na and Dong Oh Kang of the Cardiovascular Center, and

 

Professor Chi Kyung Kim of the Neurological Disorders Center),

 

cardiopulmonary coupling (CPC) analysis using Holter monitoring can

 

predict the SDB in patients who are at the early stage of stroke and predict the

 

level of recovery from neurological impairment due to stroke.

 

 

CPC analysis is a technique that uses ECG-derived spectrographic markers to

 

characterize sleep stability. When a patient experiences breathing disorder

 

during sleep, narrow-band (NB) coupling, a characteristic pattern, is observed.

 

CPC analysis can be performed using the simple and widely available Holder

 

monitoring.

 

 

According to the results of the research, the presence of NB coupling during

 

sleep time was an independent predictor of both severe functional impairment

 

(odds ratio of 3.98) and persistent functional impairment (odds ratio of 1.81) 3

 

months after stroke. Also, it was found that the longer the duration of the

 

breathing disorder during sleep reflected in the ECG, the greater the risk of

 

severe neurological impairment.

 

 

“The present study clearly demonstrates the prognostic impact of SDB by using

 

ECG-derived spectrographic markers in patients with acute stroke. Compared

 

with the conventional polysomnography, which has limited feasibility in acute

 

settings, the CPC analysis shows greater feasibility in terms of simplicity and

 

accessibility.” The research team stated. “It is expected to contribute

 

significantly to the prediction and treatment of neurological impairment in

 

stroke patients with an accurate and simple test method for the early diagnosis

 

of sleep-disordered breathing.”

 

 

The paper “Impact of Sleep-Disordered Breathing on Functional Outcomes in

 

Ischemic Stroke: A Cardiopulmonary Coupling Analysis” was published in the

 

January 2020 issue of Stroke, a world-renown journal issued by AHA/ASA,

 

receiving international attention.

 

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