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Subject A Multidisciplinary Study of Parkinson’s Disease to Analyze the Relationship with the Onset and Cancer and Cardiovascular Disease
Selection News Date 2020-06-29 Read 764

A Multidisciplinary Study of Parkinson’s

Disease to Analyze the Relationship with

the Onset and Cancer and Cardiovascular




Patients with Parkinson’s Disease Are Reported to Have a


Significantly Lower Overall Cancer Incidence Rate but at Greater


Risk of Skin Cancer and Cardiovascular Disease



A multidisciplinary research team of Korea University Ansan Hospital


(Professor Joo-Hyun Park and Professor Do-Hoon Kim of Department of


Family Medicine, Professor Do-Young Kwon of Department of Neurology,


Professor Hwa Jung Ryu of Department of Dermatology, Professor Kyung-do


Han of Department of Statistics and Actuarial Science of Soongsil University)


analyzed the incidence and prevalence rate of Parkinson’s disease in Korea and


its correlation with cancer and cardiovascular disease through a cohort study


using the national health insurance’s national health information.



Parkinson’s disease causes tremor and muscle stiffness due to the loss of


dopamine, neurotransmitter, because of the degeneration of neurons in the


substantia nigra in the brain. According to the analysis of Parkinson’s disease in


Korea from 2010 to 2015, the prevalence rate and incidence rate of women were


60% and 40% respectively, higher than that of men. Especially since 2013, the


increase was worsening. The analysis shows that change in perception about


patients with Parkinson’s disease and management is needed.



There is a lot of controversy over the incidence rate of cancer in patients with


Parkinson’s disease. According to a study on Americans and Europeans


analyzing the correlation between Parkinson’s disease, a degenerative disease,


and cancer, a proliferative disease, cancer risk was lower for patients with


Parkinson’s disease than the general population. However, a recent study on


Taiwanese reported that the incidence rate of cancer in patients with Parkinson’s


disease was higher, stirring controversy. Because economic status and genetic


characteristics differ, a Korean-specific study was conducted.



As a result of a follow-up of 2,022,852.6 person-years of Parkinson’s patients in


Korea, the overall risk of cancer was significantly lower than that of the general


population. For almost all kinds of cancer including laryngeal cancer, stomach


cancer, colorectal cancer, liver cancer, pancreatic cancer, lung cancer, the risk


was lower by up to 50%, but in a skin cancer study that was co-conducted,


incidence risk of melanoma, malignant skin cancer, was 2.8 times higher for


men over 65 years old, and 1.3 times higher for women over 65 years old,


signifying the importance of paying attention to elderly patients with


Parkinson’s disease for developing melanoma.



In a study investigating the relationship with major cardiovascular disease,


another big cause of death for the elderly population along with Parkinson’s


disease which is a degenerative condition, patients with Parkinson’s disease had


a 43% increase in the risk of myocardial infarction, 42% increase in the risk of


stroke, and 65% increase in the risk of heart failure, demonstrating the


importance of not only the management of Parkinson’s disease but also the


management of a cardiovascular disease.



The research team’s papers were published in world’s best journals such as


Circulation (5-year Impact Factor of 20.47, top 0.37% of JCR), European


Journal of Cancer (5-year Impact Factor of 6.73, top 10.2% of JCR), Journal of


the European Academy of Dermatology and Venereology (5-year Impact Factor


of 4.15, top 9.8% of JCR), BMC Geriatrics (5-year Impact Factor of 3.458, top


38.7% of JCR), proving the team’s excellence.



“The study analyzed the correlation between Parkinson’s disease and various


diseases based on the data containing all Parkinson’s disease patients who are


registered as a rare incurable disease in the National Health Insurance Service


with multiple departments such as Family Medicine, Neurology, and


Dermatology,” Korea University Ansan Hospital research team participating in


the study said. “Unlike previous studies, this study was conducted on Koreans


so it could be applicable in patient-specific treatment and management for


dementia in Korea.”

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